(I think) the ISB is reasonable. Cummins made a couple of stinkers, but I don't remember which was which. It might be the ISC I'm thinking of. Regardless, you need to check coolant level frequently. I think it's the ISB that suffered frequent egr cooler failures. If coolant disappears and isn't leaking externally, I immediately suspect the egr cooler. It's expensive, but easy to replace. Other than that, this should be a good engine.
Those two transmissions are essentially equally efficient.
What will make the biggest difference is the ratio of the gears in the rear end. You don't want to be running high rpm down the interstate all day, you'd rather be turning near the torque peak. A numerically high gearset is great if you're doing inner-city delivery, but on the highway you'll be begging for another gear. Which gearset do you want? I don't know. Calculating that takes some time. You need to test drive each truck you're interested in for at least half an hour (preferably longer) including time on the highway. Youll be able to tell, I think.
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From the info they provided, it's 5.57.