Axle ratios are expressed as the number of revolutions of the transmission's output to turn the wheels once. A 4.11 rear axle ratio is lower geared than a 3.73. The drive shaft will need to make 4.11 revolutions to turn the wheels once. So the higher the number, the lower the gearing. For highway driving a higher gear ratio, like a 3.73 is more fuel efficient.
Transmission gearing also affects fuel mileage. The Transits have a 6 speed transmission with the top two gears being overdrive. Choosing the right combination for your specific use is important. Geared too high your vehicle could spend too much time in the 5th gear at highway speeds with excessive downshifting.