Normally, how close would a couple have to live to the company they are working for?
I drove for CRST and Swift in the past and was expected to live fairly close to a terminal, but realize that the people advertising for teams here have no terminals.
Expedite is different than TL/LTL. First, you don't work for a company, driving their equipment. You are an independent contractor, leased to a carrier [there are exceptions, but few that a newbie might find], driving your own vehicle, or one belonging to a fleet owner. with many of the larger carriers, the only time you need to be at the terminal is for orientation. Many are located in the midwest areas where you can get there pretty often, but you generally aren't coming from home when you do.
Home is a potential issue if you want/need to get there on a regular or frequent basis, and live somewhere the loads just don't go very often: Fl, the west coast, Montana....
Also, I have experience, but my wife has none. Would that normally be a problem?
I'm guessing your experience is with the TL/LTL area, and as I said, expedite is different. Whether your wife's lack of experience matters depends on a lot of things: which vehicle [van, Sprinter, straight truck, T/T] you want to drive, which carrier you go with [some are better for teams, which you won't be until/unless your wife becomes licensed], whether the fleet owner you'll drive for will take a solo - there is a decided preference for teams in expedite.
The usual advice is to drive for an owner for a year or so, and that certainly seems like what you intend to do. I can't tell what you hope to drive, though, and feel obligated to point out that a cargo van is generally not a lucrative enough vehicle to support both an owner and a team.
If you can offer more details, we can offer better advice, ok? 
Alan
