We brought our hound, Max, a Jack Russel and Whippet mix, along with us in the straight truck. His schedule really hasn't changed, at least not a degree sufficient that we've had to plan extra stops on any given run. We tend to drive about 3-4 hours at a time before taking a break and that's when we all get out of the truck to stretch and evacuate bladder and bowel. Max is kind of excitable, especially when he knows/thinks he's going to get to go outside (ie when we pull the parking break, he jumps from the bed to the cab and stares at whoever is driving to take him out.
As far as feeding and water, we have bowls for food and water, we only keep the water bowl about half-full as it tends to slosh around while we're driving, and his food bowl is usually kept full as he doesn't have a problem with over eating, he'll eat what he wants (as he does at home) and then go up to the cab for a pat on the head, or head to the bed to sleep, usually the latter if one of us back there sleeping, he likes to get under the covers and sleep.
When Holly and I are both up front he likes to sit in the passenger's lap and look out the window and see what he can see, if we're off the highway driving to a shipper or con, we'll roll the window down and let him stick his nose out. Generally, Max has done well with car rides and the like, he occasionally gets motion sickness, but seems to very content with his situation inside and outside of the truck.
The only problem we run into is being places where it is impractical to let him out and let him run and play, as he has a need to do this every once in a while. We keep a frisbee and a rope in the truck so when we get to places that have big open areas away from traffic we'll cut him loose and he'll run and chase for a little while. He's not a constant high energy dog, so affording him that opportunity 3-4 times a week is usually sufficient to keep him a happy dog.