From the research I've done you will have to replace filters after you've used it, or pull your tank and clean it 100% and get all the scum out. they say B20 (20% biodiesel is good for most trucks less than 10 years old), depends on hoses and types of rubebr used in the fuel system
Also, biodiesel will gel once it starts getting below 40 degrees depending upon the type of oil used (imported biod uses palm oil which is about the worst.) Usually a tank heater(electric, low voltage in the gas tank cap or submersed in the tank) will fix that problem, but then theres the line from the tank to the engine that can gel and clog when the truck is off overnight in cold weather. If in doubt, buy a gallon and leave it outside overnight and see what it loooks like below 40.
Most people say an increase of 1-1.5mpg on most big engines, more on smaller, and a 10% increase in HP, and thats by statistic, not opinion.