I drive the 401 nightly from London to Toronto. The Woodstock to Kitchener stretch is the worst, since it is still 2 lanes each way with just a narrow ditch median. They are working on widening to 3 lanes each side with a wall in between, and this should be done late 2008, so the highway from west of London right through Toronto will be a little nicer to drive on.
Unfortunately the last several years have seen an influx of non-English speaking people from warm weather countries who don't mind driving for 35 cpm (CDN) for the latest fly by night company hauling auto parts, and these people don't have much snow/ice experience.
I can't remember the last truck I saw pulled over by the Ontario Provincial Police. You pretty much have to be above 70 to even turn their head, and faster than that to make the good officer decide to get out of his warm cruiser on a chilly night.