Leaving the money out of it, it's still a matter of preference, assuming one is qualified to drive either.
A straight truck is more comfortable, but the tradeoff is that it won't go places a van can, like the drive through windows.
A straight truck is eligible for more loads, because it can handle a vanload, (I have one onboard right now) but the driver must log, and is subject to HOS and scales.
A straight truck is limited to fueling at specific places, but the drivers can literally 'look down on' 4 wheelers, lol. (Doesn't do much for me, but some of the guys enjoy it very much)
A straight truck has room for much more of the 'comforts of home', but when you go home, it won't fit in your driveway, most likely, so you have to shlep the comforts to & from wherever it's parked instead.
It's all according to what you prefer to deal with every day, but in general, if you want to go home more often, a van makes it easier. If you can stay out for long periods, a straight truck makes it more comfortable. (There are exceptions - some vans are pretty nice, I know).
And if you tend to 'job hop' - the stickers come off a van a lot easier....