If the load you are hauling does not require placards, you are not required by the DOT to have a HAZMAT endorsement.
It's that simple. I don't know why that is so confusing to so many people.
It doesn't matter what the load is, what kind of pretty pictures it has on the packaging, or what it says on the papers, if it doesn't require placards, it doesn't require a HAZMAT endorsement.
It certainly behooves cargo van drivers to learn as much as they can about the HAZMAT endorsement and HAZMAT procedures, if for no other reason than to prevent a shipper from erroneously putting a load on your van that requires placarding. If that happens, it's all on you. I've had 3 different loads now that the shippers said didn't require placards, yet they all did. The paperwork had to be corrected and placards affixed before I left the shipper.
Panther requires cargo van drivers to have a CDL, they do not however require a CDL with a HAZMAT endorsement. The CDL can be an A, B or a C. In the case of a Class C-CDL, it must have an endorsement of some kind, since a Class-C CDL without an endorsement doesn't exist, but that endorsement can be either HAZMAT or Passenger.