My Sprinter gets its best fuel mileage at 63 MPH. It's generally right around 24.4 MPG at that speed, but of course heavy headwinds and crosswinds will have a pronounced effect on that. So do tailwinds. Depending on traffic, routing, scheduled delivery times, etc., I'll usually drive at or near the posted speed limit, which gives me an overall MPG of 21-22.
On long and relatively flat roadways, if the rest of the traffic, especially the big trucks, are mostly running at 65, like on the Turnpike, I'll sit back and Cruise at 63, which accomplishes two things. One, it's the best speed for fuel mileage, anyway, and two, the "long distance drafting" effect I get by having other vehicles pass me and then pull me along , increases the 24MPG I get to often stoopid numbers, like the 28.8 I got last night across Ohio and Indiana.
Slow and steady, even in expediting, wins the race - Aesop