It is a gorgeous drive (at least west of Denver), but yes if you are heavy can be a lot of work. In the winter make sure you have Chains or be prepared to sit. They do not accept cables all of the time especially on Eisenhour. They do a good job of trying to keep it clear, but if it tell trucks to pull over don't play stupid. They are trying to protect you and the rest of the motoring public. If they tell you to chain, chain or sit. Also in spring and winter there will sometimes be high wind warnings. If you are loaded 20k or less heed the warning and pull over. It doesn't happen that often, but it only takes a minute and the right wind gust for you to be upside down and sideway. If you wait until the sun goes down in these situations, usually the wind will subside too. It isn't something to be avoided, Flagstaff can be just as bad or worse and so can Sherman in WY and the 3 sisters in WY and Battle Mtn in Nevada. Just use your head, pay attention and listen to the weather first. Be careful of detours, sometimes it is worth it to sit and hour or 2 than try to wind a T/T down some of those roads. If you get the chance out of Pueblo try Monarch, it is a gorgeous drive too and you make ok time.