Unfortunately, all the pluses that van owners list for driving a van in expediting are the same things that make it so easy for someone to just get a van and jump into this.
So with companies just loading up with them (ala Panther), there soon may be a expedited van at every street corner
To rakow25, probably the hardest thing for you to get used to will be the OTR lifestyle. I would do what greg suggested, get on with a company, try the OTR thing. Find out if you can stand the lifestyle.
If you can, call the expedited companies, some maintain lists of fleet owners who are looking for drivers. Also check the ads on this site.
Good luck.