Absolutely! It saves money [tolls are lower for Pass holders], time [lanes are faster, can download the whole week or month from online for reimbursement & records], and aggravation [try leaving a booth while trying to not lose the change & receipt, roll up the window, shift gears, figure out which lane you need, figure out which lane everyone around you is aiming for, all at the same time!]
Someone did some research a few years ago and said Illinois offers the best program/deal, but I don't imagine there's all that much difference. Except for some outliers [Florida, Oklahoma], EZ Pass is accepted just about everywhere we go, and it's wonderful to cross "keep money handy for unexpected tolls" off the list of things to keep up with.