Sounds like your decision is made already asking what truck to buy. You've been trucking long enough to know what you are getting into. AS far as the truck, back in 2007, we went class 7, single axle, 22 dry box M2 repo w/ 75k miles w/ a Cat C9, a 335 horse mid range engine no longer available, and still driving it today. Today I would recommend a Cascadia for drive train longevity and fuel economy. Watch out for the 2010 to 2013's when dpf's were substandard and cost a fortune to repair/replace. My wife and I jumped out of admin type careers 11 years ago when she was 45, me 50, to see the country, and see the country we did, visiting friends and just plain adventure from Anchorage to New Foundland, west coast, east coast, southern half of Canada, all of the USA. Went w/ Panther, no experience, drove for a fleet owner 1st yr, then bought our own, still w/ Panther today, no reefer, no liftgate, knowing that we could make good money equipped like this, (grossed 230k 1st yr, slacked off some after it was paid for w/ more home time). Know your numbers, cost per mile. Dispatch seemed to negotiate better w/ the Mrs. so I let her do the negotiating and went w/ her on most decisions, happy wife=happy life. Get your gov't clearance, hazmat, passports. The gov't team has really made it much more pleasant at Panther for us, even paid to fly the wife home 1200 miles when we couldn't deliver on time once.
Fast forward to today, even tho we have Donvel air ride and keep the shocks fresh, the bouncing and long term driving started to take a toll on the Mrs., but, she used her time wisely, audio books on health and self sustained gardening, farming, along w/ ideas from pinterest (IK) she has now earned a well deserved retirement to spend more grounded time w/ the grandies at home gardening, making jam, art etc. as I continue to happily support her running solo and enjoy what I'm doing. The travel in the big city traffic (she drove most days, me nites) has grown our appreciate for the small town atmosphere where we have owned a home for the last 30 where as before, she wanted to move back to Dallas whence we came, not any more. I can take off when I want, for as long as I want. I turn a lot of wrenches on the ole girl and keep her polished, but this I enjoy and has paid us well. You would be wise to make things comfy for the Mrs., i.e; minimum 98 in sleeper, sleepdog matress, get a ultra quiet Honda EU2000 (no sales tax in OR) w/ a quality install in a side box, UL listed wiring, schumacker battery tender so you can shut the inverter off (recommend a 3000 watt Xantax? inverter when driving, lasts forever) . In the other side box carry a 2 gallon safety metal gas can w/ spring cap, because you will want to be "on-the-grid" when doing a layover. A gallon in the genny and 2 in the can will last you 30 plus hours.
Str8's are accepted at all the state parks we've parked at so far, use them when you know Friday your pickup isn't untill Monday, drive on the beach in TX, take the back roads when you have time, even stopped in British Columbia and panned for gold and found a speck, floated the ferry for 8 hours to New Foundland, and get paid well, especially when going way out. Panther has always paid enough to get back to the primary areas after going way out. It is what you make of it. We have seen so many landmarks most can only dream of seeing in a lifetime. Best of luck! Oh, forgive me for a double take at your wife, ck out this photo of my little sister here;
Diane Beckett: An iron lady whose faith rebuilt her family